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==Structural Insights into Human S100B and Basic Fibroblast Growth Factor (FGF2) Interaction==
==Structural Insights into Human S100B and Basic Fibroblast Growth Factor (FGF2) Interaction==
<StructureSection load='2m49' size='340' side='right' caption='[[2m49]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2m49' size='340' side='right'caption='[[2m49]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2m49]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M49 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2m49]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M49 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bfg|1bfg]], [[1uwo|1uwo]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FGF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), S100B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m49 OCA], [https://pdbe.org/2m49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m49 RCSB], [https://www.ebi.ac.uk/pdbsum/2m49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m49 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m49 OCA], [http://pdbe.org/2m49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m49 RCSB], [http://www.ebi.ac.uk/pdbsum/2m49 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FGF2_HUMAN FGF2_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:1721615</ref> <ref>PMID:8663044</ref> [[http://www.uniprot.org/uniprot/S100B_HUMAN S100B_HUMAN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization.<ref>PMID:20351179</ref> 
[https://www.uniprot.org/uniprot/FGF2_HUMAN FGF2_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:1721615</ref> <ref>PMID:8663044</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Fibroblast growth factor|Fibroblast growth factor]]
*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
*[[S100 protein|S100 protein]]
*[[S100 proteins 3D structures|S100 proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Gupta, A A]]
[[Category: Large Structures]]
[[Category: Yu, C]]
[[Category: Gupta AA]]
[[Category: Cytokine-metal binding protein complex]]
[[Category: Yu C]]
[[Category: Fgf2]]
[[Category: S100b]]
Retrieved from "https://proteopedia.org/2m49"