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==Structural Characterization of a Complex Between the Acidic Transactivation Domain of EBNA2 and the Tfb1/p62 subunit of TFIIH.==
==Structural Characterization of a Complex Between the Acidic Transactivation Domain of EBNA2 and the Tfb1/p62 subunit of TFIIH.==
<StructureSection load='2mkr' size='340' side='right' caption='[[2mkr]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mkr' size='340' side='right'caption='[[2mkr]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mkr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Ebvb9 Ebvb9]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKR FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mkr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_B95-8 Human herpesvirus 4 strain B95-8] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKR FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), BYRF1, EBNA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10377 EBVB9])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkr OCA], [http://pdbe.org/2mkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mkr RCSB], [http://www.ebi.ac.uk/pdbsum/2mkr PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkr OCA], [https://pdbe.org/2mkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkr RCSB], [https://www.ebi.ac.uk/pdbsum/2mkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST]] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref> [[http://www.uniprot.org/uniprot/EBNA2_EBVB9 EBNA2_EBVB9]] Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-associated transcription factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and CBP in order to promote transcription. Alternatively, EBNA2 can affect activities of cell cycle regulators and retard cell cycle progression at G2/M phase. It also induces chromosomal instability, by disrupting mitotic checkpoints, multi-nucleation and formation of micronuclei in infected cells.<ref>PMID:19126642</ref> 
[https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Human herpesvirus 4 strain B95-8]]
[[Category: Ebvb9]]
[[Category: Large Structures]]
[[Category: Archambault, J]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Arseneault, G]]
[[Category: Archambault J]]
[[Category: Chabot, P R]]
[[Category: Arseneault G]]
[[Category: Lussier-Price, M]]
[[Category: Chabot PR]]
[[Category: Morse, T]]
[[Category: Lussier-Price M]]
[[Category: Omichinski, J]]
[[Category: Morse T]]
[[Category: Raiola, L]]
[[Category: Omichinski J]]
[[Category: Activation]]
[[Category: Raiola L]]
[[Category: Ebna2]]
[[Category: Ebv]]
[[Category: Ph domain]]
[[Category: Tfb1]]
[[Category: Tfiih]]
[[Category: Transcription]]
[[Category: Viral protein-transcription complex]]
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