2c2x: Difference between revisions

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[[Image:2c2x.gif|left|200px]]


{{Structure
==Three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Mycobacterium tuberculosis==
|PDB= 2c2x |SIZE=350|CAPTION= <scene name='initialview01'>2c2x</scene>, resolution 2.00&Aring;
<StructureSection load='2c2x' size='340' side='right'caption='[[2c2x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2c2x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2X FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2x OCA], [https://pdbe.org/2c2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c2x RCSB], [https://www.ebi.ac.uk/pdbsum/2c2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2x ProSAT], [https://www.topsan.org/Proteins/TBSGC/2c2x TOPSAN]</span></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02882 THF_DHG_CYH_C], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00763 THF_DHG_CYH]</span>
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2x OCA], [http://www.ebi.ac.uk/pdbsum/2c2x PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2c2x RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/FOLD_MYCTU FOLD_MYCTU] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.[HAMAP-Rule:MF_01576]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c2x ConSurf].
<div style="clear:both"></div>


'''THREE DIMENSIONAL STRUCTURE OF BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE-CYCLOHYDROLASE FROM MYCOBACTERIUM TUBERCULOSIS'''
==See Also==
 
*[[Cyclohydrolase 3D structures|Cyclohydrolase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2C2X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2X OCA].
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Single protein]]
[[Category: Javid-Majd F]]
[[Category: Javid-Majd, F.]]
[[Category: Sacchettini JC]]
[[Category: Sacchettini, J C.]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: cyclohydrolase]]
[[Category: hydrolase]]
[[Category: methylenetetrahydrofolate dehydrogenase]]
[[Category: nadp]]
[[Category: oxidoreductase]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi,protein structure initiative,tb structural genomics consortium]]
[[Category: tbsgc]]
[[Category: tetrahydrofolate]]
 
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Retrieved from "https://proteopedia.org/2c2x"