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==Crystal structure of TetR transcriptional regulator SCO0520 from Streptomyces coelicolor==
==Crystal structure of TetR transcriptional regulator SCO0520 from Streptomyces coelicolor==
<StructureSection load='2q24' size='340' side='right' caption='[[2q24]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2q24' size='340' side='right'caption='[[2q24]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2q24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q24 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2q24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q24 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SCO0520, SCF6.16 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=100226 STRCO])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q24 OCA], [https://pdbe.org/2q24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q24 RCSB], [https://www.ebi.ac.uk/pdbsum/2q24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q24 ProSAT], [https://www.topsan.org/Proteins/MCSG/2q24 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q24 OCA], [http://pdbe.org/2q24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q24 RCSB], [http://www.ebi.ac.uk/pdbsum/2q24 PDBsum], [http://www.topsan.org/Proteins/MCSG/2q24 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9RJL5_STRCO Q9RJL5_STRCO]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q2/2q24_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q2/2q24_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q24 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Strco]]
[[Category: Large Structures]]
[[Category: Chruszcz, M]]
[[Category: Chruszcz M]]
[[Category: Cymborowski, M]]
[[Category: Cymborowski M]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Filippova, E V]]
[[Category: Filippova EV]]
[[Category: Gu, J]]
[[Category: Gu J]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Koclega, K D]]
[[Category: Koclega KD]]
[[Category: Structural genomic]]
[[Category: Minor W]]
[[Category: Minor, W]]
[[Category: Savchenko A]]
[[Category: Savchenko, A]]
[[Category: Xu X]]
[[Category: Xu, X]]
[[Category: Mcsg]]
[[Category: PSI, Protein structure initiative]]
[[Category: Transcription]]
[[Category: Transcriptional regulator]]

Latest revision as of 01:20, 21 November 2024

Crystal structure of TetR transcriptional regulator SCO0520 from Streptomyces coelicolor

2q24, resolution 1.80Å

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