2g2b: Difference between revisions

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[[Image:2g2b.gif|left|200px]]


{{Structure
==NMR structure of the human allograft inflammatory factor 1==
|PDB= 2g2b |SIZE=350|CAPTION= <scene name='initialview01'>2g2b</scene>
<StructureSection load='2g2b' size='340' side='right'caption='[[2g2b]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2g2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G2B FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= AIF1, G1, IBA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g2b OCA], [https://pdbe.org/2g2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g2b RCSB], [https://www.ebi.ac.uk/pdbsum/2g2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g2b ProSAT], [https://www.topsan.org/Proteins/CESG/2g2b TOPSAN]</span></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051 EFh]</span>
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g2b OCA], [http://www.ebi.ac.uk/pdbsum/2g2b PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2g2b RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/AIF1_HUMAN AIF1_HUMAN] Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.<ref>PMID:15117732</ref> <ref>PMID:16049345</ref> <ref>PMID:18699778</ref>
 
== Evolutionary Conservation ==
'''NMR structure of the human allograft inflammatory factor 1'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==Disease==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/2g2b_consurf.spt"</scriptWhenChecked>
Known disease associated with this structure: Polycystic liver disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=177060 177060]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2G2B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2B OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g2b ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: Markley JL]]
[[Category: Markley, J L.]]
[[Category: Newman CL]]
[[Category: Newman, C L.]]
[[Category: Song J]]
[[Category: Song, J.]]
[[Category: Tyler RC]]
[[Category: Tyler, R C.]]
[[Category: Vinarov D]]
[[Category: Vinarov, D.]]
[[Category: aif-1]]
[[Category: allograft inflammatory factor 1]]
[[Category: center for eukaryotic structural genomic]]
[[Category: cesg]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:25:54 2008''

Latest revision as of 18:58, 29 May 2024

NMR structure of the human allograft inflammatory factor 1

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