2h1s: Difference between revisions

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[[Image:2h1s.gif|left|200px]]


{{Structure
==Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens==
|PDB= 2h1s |SIZE=350|CAPTION= <scene name='initialview01'>2h1s</scene>, resolution 2.45&Aring;
<StructureSection load='2h1s' size='340' side='right'caption='[[2h1s]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
<table><tr><td colspan='2'>[[2h1s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H1S FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyoxylate_reductase_(NADP(+)) Glyoxylate reductase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.79 1.1.1.79] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
|GENE= GRHPR, GLXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02826 2-Hacid_dh_C], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00389 2-Hacid_dh]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h1s OCA], [https://pdbe.org/2h1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h1s RCSB], [https://www.ebi.ac.uk/pdbsum/2h1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h1s ProSAT], [https://www.topsan.org/Proteins/CESG/2h1s TOPSAN]</span></td></tr>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h1s OCA], [http://www.ebi.ac.uk/pdbsum/2h1s PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2h1s RCSB]</span>
</table>
}}
== Disease ==
 
[https://www.uniprot.org/uniprot/GRHPR_HUMAN GRHPR_HUMAN] Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:[https://omim.org/entry/260000 260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.<ref>PMID:10484776</ref>
'''Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens'''
== Function ==
 
[https://www.uniprot.org/uniprot/GRHPR_HUMAN GRHPR_HUMAN] Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
 
== Evolutionary Conservation ==
==Disease==
[[Image:Consurf_key_small.gif|200px|right]]
Known diseases associated with this structure: Hyperoxaluria, primary, type II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604296 604296]]
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/2h1s_consurf.spt"</scriptWhenChecked>
2H1S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H1S OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Glyoxylate reductase (NADP(+))]]
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h1s ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bingman, C A.]]
[[Category: Bingman CA]]
[[Category: Bitto, E.]]
[[Category: Bitto E]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: Phillips Jr GN]]
[[Category: Jr., G N.Phillips.]]
[[Category: Wesenberg GE]]
[[Category: Wesenberg, G E.]]
[[Category: center for eukaryotic structural genomic]]
[[Category: cesg]]
[[Category: glyoxylate reductase]]
[[Category: hydroxypyruvate reductase]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: q9ubq7]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:28:14 2008''

Latest revision as of 05:14, 17 October 2024

Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens

2h1s, resolution 2.45Å

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