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==Crystal structure of empty coxsackievirus A16 particle==
==Crystal structure of empty coxsackievirus A16 particle==
<StructureSection load='5c9a' size='340' side='right' caption='[[5c9a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='5c9a' size='340' side='right'caption='[[5c9a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5c9a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a16 Coxsackievirus a16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C9A FirstGlance]. <br>
<table><tr><td colspan='2'>[[5c9a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A16 Coxsackievirus A16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C9A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c9a OCA], [http://pdbe.org/5c9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c9a RCSB], [http://www.ebi.ac.uk/pdbsum/5c9a PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c9a OCA], [https://pdbe.org/5c9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c9a RCSB], [https://www.ebi.ac.uk/pdbsum/5c9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c9a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611]  Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266]  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]  
[https://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611]  Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266]  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5c9a" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5c9a" style="background-color:#fffaf0;"></div>
==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Coxsackievirus a16]]
[[Category: Coxsackievirus A16]]
[[Category: Fry, E E]]
[[Category: Large Structures]]
[[Category: Gao, Q]]
[[Category: Fry EE]]
[[Category: Hu, Z]]
[[Category: Gao Q]]
[[Category: Li, X]]
[[Category: Hu Z]]
[[Category: Rao, Z]]
[[Category: Li X]]
[[Category: Ren, J]]
[[Category: Rao Z]]
[[Category: Shen, X]]
[[Category: Ren J]]
[[Category: Stuart, D I]]
[[Category: Shen X]]
[[Category: Wang, J]]
[[Category: Stuart DI]]
[[Category: Wang, X]]
[[Category: Wang J]]
[[Category: Yang, P]]
[[Category: Wang X]]
[[Category: Zhu, L]]
[[Category: Yang P]]
[[Category: Hand-foot-and-mouth disease]]
[[Category: Zhu L]]
[[Category: Icosahedral virus]]
[[Category: Immunogenicity]]
[[Category: Picornavirus]]
[[Category: Virus]]
Retrieved from "https://proteopedia.org/5c9a"