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==Structure of a phospholipid trafficking complex with substrate==
==Structure of a phospholipid trafficking complex with substrate==
<StructureSection load='4xiz' size='340' side='right' caption='[[4xiz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4xiz' size='340' side='right'caption='[[4xiz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4xiz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XIZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4xiz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XIZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xhr|4xhr]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xiz OCA], [http://pdbe.org/4xiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xiz RCSB], [http://www.ebi.ac.uk/pdbsum/4xiz PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xiz OCA], [https://pdbe.org/4xiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xiz RCSB], [https://www.ebi.ac.uk/pdbsum/4xiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xiz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UPS1_YEAST UPS1_YEAST]] Required for maintenance of normal mitochondrial morphology as well as PCP1-dependent processing of MGM1. With UPS2, controls the level of cardiolipin in mitochondria. Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits.<ref>PMID:16754953</ref> <ref>PMID:19221197</ref> <ref>PMID:19506038</ref> <ref>PMID:20622808</ref> [[http://www.uniprot.org/uniprot/MDM35_YEAST MDM35_YEAST]] Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space.<ref>PMID:11907266</ref> <ref>PMID:20622808</ref> <ref>PMID:20657548</ref> 
[https://www.uniprot.org/uniprot/UPS1_YEAST UPS1_YEAST] Required for maintenance of normal mitochondrial morphology as well as PCP1-dependent processing of MGM1. With UPS2, controls the level of cardiolipin in mitochondria. Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits.<ref>PMID:16754953</ref> <ref>PMID:19221197</ref> <ref>PMID:19506038</ref> <ref>PMID:20622808</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: He, F]]
[[Category: Large Structures]]
[[Category: Wang, C]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Yu, F]]
[[Category: He F]]
[[Category: Zhang, P]]
[[Category: Wang C]]
[[Category: Lipid transport-oxidoreductase complex]]
[[Category: Yu F]]
[[Category: Phospholipid]]
[[Category: Zhang P]]

Latest revision as of 11:30, 6 November 2024

Structure of a phospholipid trafficking complex with substrate

4xiz, resolution 2.00Å

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