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==Crystal structure of calcium-free human adseverin domains A1-A3==
==Crystal structure of calcium-free human adseverin domains A1-A3==
<StructureSection load='5a1k' size='340' side='right' caption='[[5a1k]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='5a1k' size='340' side='right'caption='[[5a1k]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5a1k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A1K FirstGlance]. <br>
<table><tr><td colspan='2'>[[5a1k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A1K FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a1m|5a1m]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a1k OCA], [http://pdbe.org/5a1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a1k RCSB], [http://www.ebi.ac.uk/pdbsum/5a1k PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a1k OCA], [https://pdbe.org/5a1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a1k RCSB], [https://www.ebi.ac.uk/pdbsum/5a1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a1k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ADSV_HUMAN ADSV_HUMAN]] Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity).  
[https://www.uniprot.org/uniprot/SCIN_HUMAN SCIN_HUMAN] Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).[UniProtKB:Q28046][UniProtKB:Q5ZIV9][UniProtKB:Q60604]<ref>PMID:11568009</ref> <ref>PMID:26365202</ref> <ref>PMID:8547642</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chumnarnsilpa, S]]
[[Category: Homo sapiens]]
[[Category: Grimes, J M]]
[[Category: Large Structures]]
[[Category: Leyrat, C]]
[[Category: Chumnarnsilpa S]]
[[Category: Robinson, R C]]
[[Category: Grimes JM]]
[[Category: Actin]]
[[Category: Leyrat C]]
[[Category: Actin-binding protein]]
[[Category: Robinson RC]]
Retrieved from "https://proteopedia.org/5a1k"