2n7t: Difference between revisions
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New page: '''Unreleased structure''' The entry 2n7t is ON HOLD Authors: Carotenuto, A., Merlino, F., Chai, M., Brancaccio, D., Yousif, A., Novellino, E., Hruby, V., Grieco, P. Description: NMR s... |
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The | ==NMR structure of Peptide PG-992 in DPC micelles== | ||
<StructureSection load='2n7t' size='340' side='right'caption='[[2n7t]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2n7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7t OCA], [https://pdbe.org/2n7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7t RCSB], [https://www.ebi.ac.uk/pdbsum/2n7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7t ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated patho-physiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective lig-ands. Here, we report the design, synthesis, biological activity, conformational analysis and docking with receptors of two potent and selective agonists at the human MC3 receptor. | |||
Discovery of Novel Potent and Selective Agonists at the Melanocortin3 Receptor.,Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P J Med Chem. 2015 Nov 24. PMID:26599352<ref>PMID:26599352</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 2n7t" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Merlino | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Brancaccio D]] | ||
[[Category: Carotenuto A]] | |||
[[Category: Chai M]] | |||
[[Category: Grieco P]] | |||
[[Category: Hruby V]] | |||
[[Category: Merlino F]] | |||
[[Category: Novellino E]] | |||
[[Category: Yousif A]] | |||
