5aod: Difference between revisions

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'''Unreleased structure'''


The entry 5aod is ON HOLD
==Crystal structure of wild type pneumolysin.==
<StructureSection load='5aod' size='340' side='right'caption='[[5aod]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5aod]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AOD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aod OCA], [https://pdbe.org/5aod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aod RCSB], [https://www.ebi.ac.uk/pdbsum/5aod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aod ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TACY_STRR6 TACY_STRR6] A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation.[UniProtKB:P13128]


Authors: van Pee, K., Yildiz, O.
==See Also==
 
*[[Cytolysin 3D structures|Cytolysin 3D structures]]
Description: Crystal structure of wild type pneumolysin.
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Yildiz, O]]
[[Category: Large Structures]]
[[Category: Van Pee, K]]
[[Category: Streptococcus pneumoniae]]
[[Category: Yildiz O]]
[[Category: Van Pee K]]
Retrieved from "https://proteopedia.org/5aod"