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[[Image:2jrf.jpg|left|200px]]


{{Structure
==Solution NMR structure of Tubulin polymerization-promoting protein family member 3 from Homo sapiens. Northeast Structural Genomics target HR387.==
|PDB= 2jrf |SIZE=350|CAPTION= <scene name='initialview01'>2jrf</scene>
<StructureSection load='2jrf' size='340' side='right'caption='[[2jrf]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2jrf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JRF FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= TPPP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrf OCA], [https://pdbe.org/2jrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jrf RCSB], [https://www.ebi.ac.uk/pdbsum/2jrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrf ProSAT]</span></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam05517 p25-alpha]</span>
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrf OCA], [http://www.ebi.ac.uk/pdbsum/2jrf PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2jrf RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/TPPP3_HUMAN TPPP3_HUMAN] Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.<ref>PMID:17105200</ref> <ref>PMID:19633818</ref>
 
== Evolutionary Conservation ==
'''Solution NMR structure of Tubulin polymerization-promoting protein family member 3 from Homo sapiens. Northeast Structural Genomics target HR387.'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/2jrf_consurf.spt"</scriptWhenChecked>
2JRF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRF OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jrf ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Acton, T B.]]
[[Category: Acton TB]]
[[Category: Aramini, J M.]]
[[Category: Aramini JM]]
[[Category: Baran, M C.]]
[[Category: Baran MC]]
[[Category: Cunningham, K.]]
[[Category: Cunningham K]]
[[Category: Liu, J.]]
[[Category: Liu J]]
[[Category: Montelione, G T.]]
[[Category: Montelione GT]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Nwosu C]]
[[Category: Nwosu, C.]]
[[Category: Rajan PK]]
[[Category: Rajan, P K.]]
[[Category: Rossi P]]
[[Category: Rossi, P.]]
[[Category: Rost B]]
[[Category: Rost, B.]]
[[Category: Shastry R]]
[[Category: Shastry, R.]]
[[Category: Xiao R]]
[[Category: Xiao, R.]]
[[Category: nesg]]
[[Category: northeast structural genomics consortium]]
[[Category: protein structure initiative]]
[[Category: psi-2]]
[[Category: solution nmr structure]]
[[Category: structural genomic]]
 
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