5dws: Difference between revisions

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'''Unreleased structure'''


The entry 5dws is ON HOLD
==Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide==
<StructureSection load='5dws' size='340' side='right'caption='[[5dws]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5dws]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4rre 4rre]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DWS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dws OCA], [https://pdbe.org/5dws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dws RCSB], [https://www.ebi.ac.uk/pdbsum/5dws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dws ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TXNIP_HUMAN TXNIP_HUMAN] May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).<ref>PMID:17603038</ref> <ref>PMID:12821938</ref> <ref>PMID:18541147</ref> <ref>PMID:21460850</ref>


Authors: Liu, Y., Tempel, W., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
==See Also==
 
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
Description: Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Dong, A]]
__TOC__
[[Category: Min, J]]
</StructureSection>
[[Category: Liu, Y]]
[[Category: Homo sapiens]]
[[Category: Bountra, C]]
[[Category: Large Structures]]
[[Category: Tempel, W]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C.H]]
[[Category: Bountra C]]
[[Category: Edwards, A.M]]
[[Category: Dong A]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Edwards AM]]
[[Category: Liu Y]]
[[Category: Min J]]
[[Category: Tempel W]]
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