5c4t: Difference between revisions

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'''Unreleased structure'''


The entry 5c4t is ON HOLD
==Identification of a Novel Allosteric Binding Site for RORgt Inhibitors==
 
<StructureSection load='5c4t' size='340' side='right'caption='[[5c4t]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
Authors: Parthasarathy, G., Soisson, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5c4t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C4T FirstGlance]. <br>
Description: Identification of a Novel Allosteric Binding Site for RORgt Inhibitors
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4Y6:(1S)-4-{1-[2-CHLORO-6-(TRIFLUOROMETHYL)BENZOYL]-4-FLUORO-1H-INDAZOL-3-YL}-1-METHYLCYCLOHEX-3-ENE-1-CARBOXYLIC+ACID'>4Y6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Soisson, S]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c4t OCA], [https://pdbe.org/5c4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c4t RCSB], [https://www.ebi.ac.uk/pdbsum/5c4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c4t ProSAT]</span></td></tr>
[[Category: Parthasarathy, G]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Parthasarathy G]]
[[Category: Soisson S]]
Retrieved from "https://proteopedia.org/5c4t"