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==Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM59==
==Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM59==
<StructureSection load='5del' size='340' side='right' caption='[[5del]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='5del' size='340' side='right'caption='[[5del]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5del]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ryh 4ryh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DEL FirstGlance]. <br>
<table><tr><td colspan='2'>[[5del]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ryh 4ryh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DEL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D59:N-(3,5-DICHLOROPHENYL)-2-METHYL-3-NITROBENZAMIDE'>D59</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D59:N-(3,5-DICHLOROPHENYL)-2-METHYL-3-NITROBENZAMIDE'>D59</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5del FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5del OCA], [http://pdbe.org/5del PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5del RCSB], [http://www.ebi.ac.uk/pdbsum/5del PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5del FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5del OCA], [https://pdbe.org/5del PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5del RCSB], [https://www.ebi.ac.uk/pdbsum/5del PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5del ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.  
[https://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5del" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5del" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Deng, X]]
[[Category: Large Structures]]
[[Category: Phillips, M]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Alpha/beta barrel]]
[[Category: Deng X]]
[[Category: Fmn]]
[[Category: Phillips M]]
[[Category: Mitochondrial membrane]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Latest revision as of 08:46, 27 September 2023

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM59

5del, resolution 2.20Å

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