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==Crystal Structure of the Human Cytomegalovirus pUL50-pUL53 Complex==
==Crystal Structure of the Human Cytomegalovirus pUL50-pUL53 Complex==
<StructureSection load='5d5n' size='340' side='right' caption='[[5d5n]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
<StructureSection load='5d5n' size='340' side='right'caption='[[5d5n]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5d5n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D5N FirstGlance]. <br>
<table><tr><td colspan='2'>[[5d5n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D5N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d5n OCA], [http://pdbe.org/5d5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d5n RCSB], [http://www.ebi.ac.uk/pdbsum/5d5n PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d5n OCA], [https://pdbe.org/5d5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d5n RCSB], [https://www.ebi.ac.uk/pdbsum/5d5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d5n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UL50_HCMVA UL50_HCMVA]] Plays a major role in virion nuclear egress, the first step of virion release from infected cell. Viral capsids are initially assembled within the nucleus, UL53/UL50 complex induces capsids budding and envelopment into the perinuclear space. Then UL53/UL50 complex promotes fusion of perinuclear virion envelope with the outer nuclear membrane, releasing viral capsid into the cytoplasm where it will engages budding sites in the Golgi or trans-Golgi network (By similarity). [[http://www.uniprot.org/uniprot/UL53_HCMVA UL53_HCMVA]] Plays a major role in virion nuclear egress, the first step of virion release from infected cell. Viral capsids are initially assembled within the nucleus, UL53/UL50 complex induces capsids budding and envelopment into the perinuclear space. Then UL53/UL50 complex promotes fusion of perinuclear virion envelope with the outer nuclear membrane, releasing viral capsid into the cytoplasm where it will engages budding sites in the Golgi or trans-Golgi network (By similarity).  
[https://www.uniprot.org/uniprot/NEC2_HCMVM NEC2_HCMVM] Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.[HAMAP-Rule:MF_04024]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Egerer-Sieber, C]]
[[Category: Human herpesvirus 5 strain AD169]]
[[Category: Hohl, K]]
[[Category: Large Structures]]
[[Category: Muller, Y A]]
[[Category: Egerer-Sieber C]]
[[Category: Sevvana, M]]
[[Category: Hohl K]]
[[Category: Walzer, S A]]
[[Category: Muller YA]]
[[Category: Viral nuclear egress complex]]
[[Category: Sevvana M]]
[[Category: Viral protein]]
[[Category: Walzer SA]]
Retrieved from "https://proteopedia.org/5d5n"