5e5m: Difference between revisions
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New page: '''Unreleased structure''' The entry 5e5m is ON HOLD Authors: Fedorov, A.A., Fedorov, E.V., Samanta, D., Bonnano, J.B., Almo, S.C. Description: Crystal structure of mouse CTLA-4 in com... |
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The | ==Crystal structure of mouse CTLA-4 in complex with nanobody== | ||
<StructureSection load='5e5m' size='340' side='right'caption='[[5e5m]], [[Resolution|resolution]] 2.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5e5m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelidae Camelidae] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E5M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.182Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5m OCA], [https://pdbe.org/5e5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e5m RCSB], [https://www.ebi.ac.uk/pdbsum/5e5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5m ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CTLA4_MOUSE CTLA4_MOUSE] Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (By similarity). | |||
==See Also== | |||
*[[CTLA-4|CTLA-4]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Almo | [[Category: Camelidae]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: | [[Category: Almo SC]] | ||
[[Category: | [[Category: Bonanno JB]] | ||
[[Category: Fedorov AA]] | |||
[[Category: Fedorov EV]] | |||
[[Category: Samanta D]] | |||
Latest revision as of 06:13, 5 July 2023
Crystal structure of mouse CTLA-4 in complex with nanobody
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