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==Structure of Vps34 complex II from S. cerevisiae.==
==Structure of Vps34 complex II from S. cerevisiae.==
<StructureSection load='5dfz' size='340' side='right' caption='[[5dfz]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
<StructureSection load='5dfz' size='340' side='right'caption='[[5dfz]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5dfz]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DFZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5dfz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DFZ FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dfz OCA], [https://pdbe.org/5dfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dfz RCSB], [https://www.ebi.ac.uk/pdbsum/5dfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dfz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dfz OCA], [http://pdbe.org/5dfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dfz RCSB], [http://www.ebi.ac.uk/pdbsum/5dfz PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VPS38_YEAST VPS38_YEAST]] Involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through generating a specific pool of phosphatidylinositol 3-phosphate allowing the recruitment of the retromer complex proteins to the endosome). Mediates the interaction between VPS30 and the VPS34-VPS15 core complex, leading to the recruitment of VPS30 to the membrane.<ref>PMID:11157979</ref> <ref>PMID:12244127</ref> <ref>PMID:9265642</ref> [[http://www.uniprot.org/uniprot/VPS15_YEAST VPS15_YEAST]] Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole.<ref>PMID:1988155</ref> <ref>PMID:3062374</ref> <ref>PMID:1756716</ref> <ref>PMID:8387919</ref> <ref>PMID:8509446</ref> <ref>PMID:7989323</ref> <ref>PMID:8649377</ref> <ref>PMID:11157979</ref> <ref>PMID:12244127</ref>  [[http://www.uniprot.org/uniprot/VPS34_YEAST VPS34_YEAST]] Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Its activation by VPS15 may lead to the phosphorylation of phosphatidylinositol in the sorting compartment membrane. Finally, it might also be involved in ethanol tolerance and cell wall integrity.<ref>PMID:11157979</ref> <ref>PMID:11523784</ref> <ref>PMID:12244127</ref> <ref>PMID:2247081</ref> <ref>PMID:2555343</ref> <ref>PMID:3062374</ref> <ref>PMID:7929582</ref> <ref>PMID:7989323</ref> <ref>PMID:8385367</ref> <ref>PMID:8387919</ref>  [[http://www.uniprot.org/uniprot/BECN1_YEAST BECN1_YEAST]] Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Plays also a role in regulation of filamentous growth.<ref>PMID:11157979</ref> <ref>PMID:11689437</ref> <ref>PMID:12244127</ref> <ref>PMID:16267277</ref> <ref>PMID:17404498</ref> <ref>PMID:17700056</ref> <ref>PMID:18182384</ref> <ref>PMID:18701704</ref> <ref>PMID:19131141</ref> <ref>PMID:22437838</ref> <ref>PMID:23878393</ref> <ref>PMID:8224160</ref> <ref>PMID:9105038</ref> <ref>PMID:9712845</ref> 
[https://www.uniprot.org/uniprot/VPS38_YEAST VPS38_YEAST] Involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through generating a specific pool of phosphatidylinositol 3-phosphate allowing the recruitment of the retromer complex proteins to the endosome). Mediates the interaction between VPS30 and the VPS34-VPS15 core complex, leading to the recruitment of VPS30 to the membrane.<ref>PMID:11157979</ref> <ref>PMID:12244127</ref> <ref>PMID:9265642</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5dfz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5dfz" style="background-color:#fffaf0;"></div>
==See Also==
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Phosphatidylinositol 3-kinase]]
[[Category: Lama glama]]
[[Category: Ohashi, Y]]
[[Category: Large Structures]]
[[Category: Rostislavleva, K]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Soler, N]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Williams, R L]]
[[Category: Ohashi Y]]
[[Category: Zhang, L]]
[[Category: Rostislavleva K]]
[[Category: Autophagy]]
[[Category: Soler N]]
[[Category: Bara]]
[[Category: Williams RL]]
[[Category: C2]]
[[Category: Zhang L]]
[[Category: Coiled-coil]]
[[Category: Complex ii]]
[[Category: Heat]]
[[Category: Kinase]]
[[Category: Lipid]]
[[Category: Nanobody]]
[[Category: Pi3p]]
[[Category: Transferase]]
[[Category: Vacuolar protein sorting]]
[[Category: Vps15]]
[[Category: Vps30]]
[[Category: Vps34]]
[[Category: Vps38]]
[[Category: Wd40]]
[[Category: Yeast]]
Retrieved from "https://proteopedia.org/5dfz"