2n6h: Difference between revisions
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==NMR structure for a 2-stranded parallel beta-sheet== | |||
<StructureSection load='2n6h' size='340' side='right'caption='[[2n6h]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2n6h]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N6H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4G6:2-METHYLPROPANE-1,2-DIAMINE'>4G6</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n6h OCA], [https://pdbe.org/2n6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n6h RCSB], [https://www.ebi.ac.uk/pdbsum/2n6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n6h ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We have examined whether parallel beta-sheet secondary structure becomes more stable as the number of beta-strands increases, via comparisons among peptides designed to adopt two- or three-stranded parallel beta-sheet conformations in aqueous solution. Our three-strand design is the first experimental model of a triple-stranded parallel beta-sheet. Analysis of the designed peptides by nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopy supports the hypothesis that increasing the number of beta-strands, from two to three, increases the stability of the parallel beta-sheet. We present the first experimental evidence for cooperativity in the folding of a triple-stranded parallel beta-sheet, and we show how minimal model systems may enable experimental documentation of characteristic properties, such as CD spectra, of parallel beta-sheets. | |||
Impact of Strand Number on Parallel beta-Sheet Stability.,Kung VM, Cornilescu G, Gellman SH Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14336-9. doi: 10.1002/anie.201506448. , Epub 2015 Oct 12. PMID:26457984<ref>PMID:26457984</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Cornilescu | <div class="pdbe-citations 2n6h" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Cornilescu G]] | |||
[[Category: Gellman SH]] | |||
[[Category: Kung VM]] | |||
Latest revision as of 07:43, 9 October 2024
NMR structure for a 2-stranded parallel beta-sheet
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