2jr7: Difference between revisions

Latest revision as of 10:11, 20 December 2023

Solution structure of human DESR1

Structural highlights

2jr7 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Ligands:	ZN
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPH3_HUMAN Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (By similarity).^[1] ^[2] Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.^[3] ^[4]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Sjolinder M, Uhlmann J, Ponstingl H. Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion. Exp Cell Res. 2004 Mar 10;294(1):68-76. PMID:14980502 doi:https://dx.doi.org/10.1016/j.yexcr.2003.09.033
↑ Liu S, Leppla SH. Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins. Mol Cell. 2003 Sep;12(3):603-13. PMID:14527407
↑ Sjolinder M, Uhlmann J, Ponstingl H. Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion. Exp Cell Res. 2004 Mar 10;294(1):68-76. PMID:14980502 doi:https://dx.doi.org/10.1016/j.yexcr.2003.09.033
↑ Liu S, Leppla SH. Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins. Mol Cell. 2003 Sep;12(3):603-13. PMID:14527407

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Sjolinder M, Uhlmann J, Ponstingl H. Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion. Exp Cell Res. 2004 Mar 10;294(1):68-76. PMID:14980502 doi:https://dx.doi.org/10.1016/j.yexcr.2003.09.033

[2] Liu S, Leppla SH. Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins. Mol Cell. 2003 Sep;12(3):603-13. PMID:14527407

[3] Sjolinder M, Uhlmann J, Ponstingl H. Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion. Exp Cell Res. 2004 Mar 10;294(1):68-76. PMID:14980502 doi:https://dx.doi.org/10.1016/j.yexcr.2003.09.033

[4] Liu S, Leppla SH. Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins. Mol Cell. 2003 Sep;12(3):603-13. PMID:14527407

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-[[Image:2jr7.jpg|left|200px]]
- {{Structure
+==Solution structure of human DESR1==
-|PDB= 2jr7 |SIZE=350|CAPTION= <scene name='initialview01'>2jr7</scene>
+<StructureSection load='2jr7' size='340' side='right'caption='[[2jr7]]' scene=''>
-|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+90'>AC1</scene>
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+<table><tr><td colspan='2'>[[2jr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JR7 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE= DPH3, DESR1, ZCSL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5216 COG5216]</span>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jr7 OCA], [https://pdbe.org/2jr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2jr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jr7 ProSAT]</span></td></tr>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jr7 OCA], [http://www.ebi.ac.uk/pdbsum/2jr7 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2jr7 RCSB]</span>
+</table>
-}}
+== Function ==
+[https://www.uniprot.org/uniprot/DPH3_HUMAN DPH3_HUMAN] Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (By similarity).<ref>PMID:14980502</ref> <ref>PMID:14527407</ref>   Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.<ref>PMID:14980502</ref> <ref>PMID:14527407</ref>
-'''Solution structure of human DESR1'''
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
-==About this Structure==
+  <jmolCheckbox>
-JR7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JR7 OCA].
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/2jr7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-==Reference==
+    <text>to colour the structure by Evolutionary Conservation</text>
-Solution structure of human DESR1, a CSL zinc-binding protein., Wu F, Zhang J, Sun J, Huang H, Ji P, Chu W, Yu M, Yang F, Wu Z, Wu J, Shi Y, Proteins. 2008 Apr;71(1):514-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18214955 18214955]
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jr7 ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Shi, Y.]]
+[[Category: Shi Y]]
-[[Category: Wu, F.]]
+[[Category: Wu F]]
-[[Category: Wu, J.]]
+[[Category: Wu J]]
-[[Category: csl zinc finger]]
-[[Category: desr1]]
-[[Category: metal binding protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 09:51:20 2008''

2jr7: Difference between revisions

Latest revision as of 10:11, 20 December 2023

Solution structure of human DESR1

Structural highlights

Function

Evolutionary Conservation

References

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