5e8f: Difference between revisions
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New page: '''Unreleased structure''' The entry 5e8f is ON HOLD Authors: Fansa, E.K., OReilly, N.J., Ismail, S.A., Wittinghofer, A. Description: Structure of Fully modified geranylgeranylated PDE... |
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==Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D== | |||
<StructureSection load='5e8f' size='340' side='right'caption='[[5e8f]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5e8f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E8F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene>, <scene name='pdbligand=GER:GERAN-8-YL+GERAN'>GER</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8f OCA], [https://pdbe.org/5e8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e8f RCSB], [https://www.ebi.ac.uk/pdbsum/5e8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e8f ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
This study shows that the prenylated C-terminus of RPGR can bind to PDE6delta with high affinity, suggesting two distinct binding sites of the RPGR/PDE6delta complex. The serine residue at the -3 position relative to the prenylated cysteine seems to play a key role in defining the selectivity of PDE6delta towards ciliary prenylated cargo. [Image: see text] | |||
The N- and C-terminal ends of RPGR can bind to PDE6delta.,Fansa EK, O'Reilly NJ, Ismail S, Wittinghofer A EMBO Rep. 2015 Dec;16(12):1583-5. doi: 10.15252/embr.201541404. Epub 2015 Nov 9. PMID:26553937<ref>PMID:26553937</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5e8f" style="background-color:#fffaf0;"></div> | ||
[[Category: Ismail | |||
[[Category: | ==See Also== | ||
[[Category: | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Fansa EK]] | |||
[[Category: Ismail SA]] | |||
[[Category: O'Reilly NJ]] | |||
[[Category: Wittinghofer A]] | |||
Latest revision as of 06:16, 5 July 2023
Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D
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