Aerolysin: Difference between revisions

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<StructureSection load='1pre' size='340' side='right' caption='Proaerolysin dimer (PDB code [[1pre]]).' scene='43/430021/Cv/2'>


{{STRUCTURE_1pre| PDB=1pre | SIZE=400| SCENE=Aerolysin/Cv/1 |right|CAPTION=Proaerolysin dimer [[1pre]] }}
[[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death.  It is secreted as an inactive precursor '''proaerolysin''' (proAer) which gets cleaved at Arg-432 by furin to produce the active Aer.<ref>PMID:7510043</ref>  For toxins in Proteopedia see [[Toxins]].


[[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''.  It uses GPI-anchored proteins on the cell surface as receptors.  Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death.  It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer.  For toxins in Proteopedia see [[Toxins]].


__NOTOC__
__NOTOC__
== 3D Structures of Aerolysin ==
== 3D Structures of Aerolysin ==
[[Aerolysin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
* Aerolysin
**[[3g4n]], [[3g4o]] – Aer (mutant)
 
* Proaerolysin


**[[1pre]] - proAer<br />
== References ==
**[[3c0m]], [[3c0n]], [[1z52]] - proAer (mutant)<br />
<references/>
**[[3c0o]] - proAer (mutant)+mannose-6-phosphate
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 09:59, 21 May 2024

Proaerolysin dimer (PDB code 1pre).

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel

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