2jg2: Difference between revisions
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==HIGH RESOLUTION STRUCTURE OF SPT WITH PLP INTERNAL ALDIMINE== | ==HIGH RESOLUTION STRUCTURE OF SPT WITH PLP INTERNAL ALDIMINE== | ||
<StructureSection load='2jg2' size='340' side='right' caption='[[2jg2]], [[Resolution|resolution]] 1.30Å' scene=''> | <StructureSection load='2jg2' size='340' side='right'caption='[[2jg2]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jg2]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2jg2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JG2 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jg2 OCA], [https://pdbe.org/2jg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jg2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jg2 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SPT_SPHPI SPT_SPHPI] Catalyzes the condensation of L-serine with palmitoyl-CoA (hexadecanoyl-CoA) to produce 3-oxosphinganine (PubMed:11279212, PubMed:17557831, PubMed:17559874, PubMed:19376777). Exhibits a broad substrate specificity concerning the chain length and the degree of unsaturation of acyl-CoA (PubMed:11279212, PubMed:19376777).<ref>PMID:11279212</ref> <ref>PMID:17557831</ref> <ref>PMID:17559874</ref> <ref>PMID:19376777</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jg2_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jg2_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jg2 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 29: | Line 31: | ||
==See Also== | ==See Also== | ||
*[[Serine palmitoyltransferase|Serine palmitoyltransferase]] | *[[Serine palmitoyltransferase 3D structures|Serine palmitoyltransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Sphingomonas paucimobilis]] | ||
[[Category: Barton | [[Category: Barton GJ]] | ||
[[Category: Campopiano | [[Category: Campopiano DJ]] | ||
[[Category: Carter | [[Category: Carter LG]] | ||
[[Category: Dorward | [[Category: Dorward M]] | ||
[[Category: Johnson | [[Category: Johnson KA]] | ||
[[Category: Liu | [[Category: Liu H]] | ||
[[Category: Mcmahon | [[Category: Mcmahon SA]] | ||
[[Category: Naismith | [[Category: Naismith JH]] | ||
[[Category: Oke | [[Category: Oke M]] | ||
[[Category: Overton | [[Category: Overton IM]] | ||
[[Category: Puech | [[Category: Puech D]] | ||
[[Category: Yard | [[Category: Yard BA]] | ||
