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==The crystal structure of the GST-like domains complex of AIMP3-EPRS mutant C92SC105SC123S==
==The crystal structure of the GST-like domains complex of AIMP3-EPRS mutant C92SC105SC123S==
<StructureSection load='5bmu' size='340' side='right' caption='[[5bmu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5bmu' size='340' side='right'caption='[[5bmu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5bmu]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BMU FirstGlance]. <br>
<table><tr><td colspan='2'>[[5bmu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BMU FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--tRNA_ligase Glutamate--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.17 6.1.1.17] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bmu OCA], [http://pdbe.org/5bmu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bmu RCSB], [http://www.ebi.ac.uk/pdbsum/5bmu PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bmu OCA], [https://pdbe.org/5bmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bmu RCSB], [https://www.ebi.ac.uk/pdbsum/5bmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bmu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MCA3_HUMAN MCA3_HUMAN]] Positive modulator of ATM response to DNA damage. [[http://www.uniprot.org/uniprot/SYEP_HUMAN SYEP_HUMAN]] Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.<ref>PMID:1756734</ref> <ref>PMID:15479637</ref> <ref>PMID:23071094</ref> 
[https://www.uniprot.org/uniprot/MCA3_HUMAN MCA3_HUMAN] Positive modulator of ATM response to DNA damage.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5bmu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5bmu" style="background-color:#fffaf0;"></div>
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glutamate--tRNA ligase]]
[[Category: Homo sapiens]]
[[Category: Cho, H J]]
[[Category: Large Structures]]
[[Category: Kang, B S]]
[[Category: Cho HJ]]
[[Category: Aimp3]]
[[Category: Kang BS]]
[[Category: Epr]]
[[Category: Gst-like domain]]
[[Category: Translation-ligase complex]]

Latest revision as of 16:04, 8 November 2023

The crystal structure of the GST-like domains complex of AIMP3-EPRS mutant C92SC105SC123S

5bmu, resolution 2.60Å

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