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==Human skeletal calsequestrin, D210G mutant low-calcium complex==
==Human skeletal calsequestrin, D210G mutant low-calcium complex==
<StructureSection load='5cre' size='340' side='right' caption='[[5cre]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
<StructureSection load='5cre' size='340' side='right'caption='[[5cre]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5cre]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CRE FirstGlance]. <br>
<table><tr><td colspan='2'>[[5cre]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CRE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.315&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5crh|5crh]], [[5crd|5crd]], [[5crg|5crg]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cre OCA], [http://pdbe.org/5cre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cre RCSB], [http://www.ebi.ac.uk/pdbsum/5cre PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cre OCA], [https://pdbe.org/5cre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cre RCSB], [https://www.ebi.ac.uk/pdbsum/5cre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cre ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CASQ1_HUMAN CASQ1_HUMAN]] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.<ref>PMID:22337878</ref> <ref>PMID:22337878</ref>
[https://www.uniprot.org/uniprot/CASQ1_HUMAN CASQ1_HUMAN] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.<ref>PMID:22337878</ref> <ref>PMID:22337878</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Kang, C]]
[[Category: Homo sapiens]]
[[Category: Lewis, K M]]
[[Category: Large Structures]]
[[Category: Ronish, L A]]
[[Category: Kang C]]
[[Category: Calcium binding protein]]
[[Category: Lewis KM]]
[[Category: Calsequestrin calcium-binding protein]]
[[Category: Ronish LA]]
Retrieved from "https://proteopedia.org/5cre"