5a1n: Difference between revisions

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'''Unreleased structure'''


The entry 5a1n is ON HOLD  until May 03 2017
==The crystal structure of the GST-like domains complex of EPRS-AIMP2 mutant S156D==
<StructureSection load='5a1n' size='340' side='right'caption='[[5a1n]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5a1n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A1N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a1n OCA], [https://pdbe.org/5a1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a1n RCSB], [https://www.ebi.ac.uk/pdbsum/5a1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a1n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYEP_HUMAN SYEP_HUMAN] Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.<ref>PMID:1756734</ref> <ref>PMID:15479637</ref> <ref>PMID:23071094</ref>


Authors: Cho, H.Y., Choi, Y.S., Kang, B.S.
==See Also==
 
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
Description: The crystal structure of the GST-like domains complex of EPRS-AIMP2 mutant S156D
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Cho, H.Y]]
__TOC__
[[Category: Kang, B.S]]
</StructureSection>
[[Category: Choi, Y.S]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cho HY]]
[[Category: Choi YS]]
[[Category: Kang BS]]
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