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'''Unreleased structure'''


The entry 5epo is ON HOLD  until Paper Publication
==The three-dimensional structure of Clostridium absonum 7alpha-hydroxysteroid dehydrogenase==
<StructureSection load='5epo' size='340' side='right'caption='[[5epo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5epo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_sardiniense Clostridium sardiniense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EPO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TUD:TAUROCHENODEOXYCHOLIC+ACID'>TUD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5epo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5epo OCA], [https://pdbe.org/5epo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5epo RCSB], [https://www.ebi.ac.uk/pdbsum/5epo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5epo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HDHA_CLOSR HDHA_CLOSR] 7alpha-hydroxysteroid dehydrogenase that catalyzes the NADP(+)-dependent oxidation of the 7alpha-hydroxy group of 7alpha-hydroxysteroids, such as cholate, chenodeoxycholate, glycochenodeoxycholate and taurochenodeoxycholate, to the corresponding 7-oxosteroids (PubMed:22198717, PubMed:24810359). Is also able to catalyze the reverse reduction reactions (PubMed:22198717). Together with 7beta-HSDH encoded in the adjacent gene, is likely involved in the epimerization of the hydroxy group at C-7 of primary bile acids through 7-keto bile acid intermediates (PubMed:22198717).<ref>PMID:22198717</ref> <ref>PMID:24810359</ref>


Authors: Lou, D., Wang, B., Wang, F.
==See Also==
 
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
Description: The three-dimensional structure of Clostridium absonum 7alpha-hydroxysteroid dehydrogenase
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Wang, B]]
__TOC__
[[Category: Lou, D]]
</StructureSection>
[[Category: Wang, F]]
[[Category: Clostridium sardiniense]]
[[Category: Large Structures]]
[[Category: Lou D]]
[[Category: Wang B]]
[[Category: Wang F]]
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