5esu: Difference between revisions
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==Crystal Structure of M. tuberculosis MenD bound to Mg2+ and Covalent Intermediate II (a ThDP + de-carboxylated 2-oxoglutarate + Isochorismate adduct)== | |||
<StructureSection load='5esu' size='340' side='right'caption='[[5esu]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5esu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ESU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TOI:(1~{R},2~{S},5~{S},6~{S})-2-[(1~{S})-1-[3-[(4-AZANYLIDENE-2-METHYL-1~{H}-PYRIMIDIN-5-YL)METHYL]-4-METHYL-5-[2-[OXIDANYL(PHOSPHONOOXY)PHOSPHORYL]OXYETHYL]-1,3-THIAZOL-3-IUM-2-YL]-1,4-BIS(OXIDANYL)-4-OXIDANYLIDENE-BUTYL]-6-OXIDANYL-5-(3-OXIDANYL-3-OXIDANYLIDENE-PROP-1-EN-2-YL)OXY-CYCLOHEX-3-ENE-1-CARBOXYLIC+ACID'>TOI</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5esu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esu OCA], [https://pdbe.org/5esu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5esu RCSB], [https://www.ebi.ac.uk/pdbsum/5esu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5esu ProSAT]</span></td></tr> | ||
[[Category: Bashiri | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/MEND_MYCTU MEND_MYCTU] Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Baker EN]] | |||
[[Category: Bashiri G]] | |||
[[Category: Bulloch EMM]] | |||
[[Category: Jirgis ENM]] | |||
[[Category: Johnston JM]] | |||
Latest revision as of 07:22, 1 May 2024
Crystal Structure of M. tuberculosis MenD bound to Mg2+ and Covalent Intermediate II (a ThDP + de-carboxylated 2-oxoglutarate + Isochorismate adduct)
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