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==Crystal structure of E. coli FabI bound to the thiocarbamoylated benzodiazaborine inhibitor 35b.==
==Crystal structure of E. coli FabI bound to the thiocarbamoylated benzodiazaborine inhibitor 35b.==
<StructureSection load='5cg2' size='340' side='right' caption='[[5cg2]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
<StructureSection load='5cg2' size='340' side='right'caption='[[5cg2]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5cg2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CG2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5cg2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CG2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CJ3:1-HYDROXY-2,3,1-BENZODIAZABORININE-2(1H)-CARBOTHIOAMIDE'>CJ3</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cfz|5cfz]], [[5cg1|5cg1]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CJ3:1-HYDROXY-2,3,1-BENZODIAZABORININE-2(1H)-CARBOTHIOAMIDE'>CJ3</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cg2 OCA], [https://pdbe.org/5cg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cg2 RCSB], [https://www.ebi.ac.uk/pdbsum/5cg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cg2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cg2 OCA], [http://pdbe.org/5cg2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cg2 RCSB], [http://www.ebi.ac.uk/pdbsum/5cg2 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI]] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>
[https://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5cg2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5cg2" style="background-color:#fffaf0;"></div>
==See Also==
*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Jordan, C A]]
[[Category: Escherichia coli K-12]]
[[Category: Vey, J L]]
[[Category: Large Structures]]
[[Category: Antibiotic]]
[[Category: Jordan CA]]
[[Category: Enoyl-acp reductase]]
[[Category: Vey JL]]
[[Category: Nad]]
[[Category: Oxidoreducatase-oxidoreducatase inhibitor complex]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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