5ako: Difference between revisions

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'''Unreleased structure'''


The entry 5ako is ON HOLD  until Paper Publication
==The complex of Tse2 and Tsi2 from Pseudomonas aeruginosa==
<StructureSection load='5ako' size='340' side='right'caption='[[5ako]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ako]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AKO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ako FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ako OCA], [https://pdbe.org/5ako PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ako RCSB], [https://www.ebi.ac.uk/pdbsum/5ako PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ako ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TSI2_PSEAE TSI2_PSEAE] Immunity protein that plays a role in preventing early activation of toxin Tse2. Binds to a large surface of Tse2 and thereby occludes the active site to specifically inhibits Tse2.<ref>PMID:22310046</ref> <ref>PMID:22511866</ref> <ref>PMID:26749446</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Tse2 is a cytoactive toxin secreted by a type six secretion apparatus of Pseudomonas aeruginosa. The Tse2 toxin naturally attacks a target in the cytoplasm of bacterial cells, and can cause toxicity if artificially introduced into eukaryotic cells. The X-ray crystal structure of the complex of Tse2 and its cognate immunity protein Tsi2 revealed a heterotetrameric structure with an extensive binding interface. Structural identity was found between Tse2 and NAD-dependent enzymes, especially ADP-ribosylating toxins, which facilitated the identification of the Tse2 active site and revealed it to be occluded upon binding the inhibitor Tsi2. The structural identity shared with NAD-dependent enzymes, including conserved catalytic residues, suggests that the mechanism of Tse2 toxicity may be NAD dependent.


Authors: Robb, C.S., Nano, F.E., Boraston, A.B.
The Structure of the Toxin and Type Six Secretion System Substrate Tse2 in Complex with Its Immunity Protein.,Robb CS, Robb M, Nano FE, Boraston AB Structure. 2015 Dec 28. pii: S0969-2126(15)00501-8. doi:, 10.1016/j.str.2015.11.012. PMID:26749446<ref>PMID:26749446</ref>


Description: The complex of Tse2 and Tsi2 from Pseudomonas aeruginosa
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Boraston, A.B]]
<div class="pdbe-citations 5ako" style="background-color:#fffaf0;"></div>
[[Category: Nano, F.E]]
== References ==
[[Category: Robb, C.S]]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Boraston AB]]
[[Category: Nano FE]]
[[Category: Robb CS]]
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