5cc1: Difference between revisions

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'''Unreleased structure'''


The entry 5cc1 is ON HOLD  until Paper Publication
==S425G Glucocorticoid receptor DNA binding domain - (+)GRE complex==
<StructureSection load='5cc1' size='340' side='right'caption='[[5cc1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5cc1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CC1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.302&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cc1 OCA], [https://pdbe.org/5cc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cc1 RCSB], [https://www.ebi.ac.uk/pdbsum/5cc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cc1 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
== Function ==
[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>


Authors: Hudson, W.H., Weikum, E.A., Ortlund, E.A.
==See Also==
 
*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
Description:  
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Hudson, W.H]]
__TOC__
[[Category: Weikum, E.A]]
</StructureSection>
[[Category: Ortlund, E.A]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Hudson WH]]
[[Category: Ortlund EA]]
[[Category: Weikum EA]]
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