5coi: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5coi is ~~ON HOLD until Paper Publication~~

==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==

== Structural highlights ==

<table><tr><td colspan='2'>[[5coi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5COI OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5COI FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=55K:1-({[(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)SULFONYL]AMINO}METHYL)CYCLOPENTANECARBOXYLIC+ACID'>55K</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5coi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5coi OCA], [https://pdbe.org/5coi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5coi RCSB], [https://www.ebi.ac.uk/pdbsum/5coi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5coi ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

~~Authors: Zhang, Y., Song, M., Liu, Z., Xue, X., Xu, Y.~~

==See Also==

*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]

~~Description~~: ~~Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd~~]~~indol-2(1H)-one ligand~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: ~~Xu, Y~~]]

__TOC__

[[Category: ~~Zhang, Y~~]]

</StructureSection>

[[Category: ~~Xue, X~~]]

[[Category: Homo sapiens]]

[[Category: ~~Liu, Z~~]]

[[Category: Large Structures]]

[[Category: ~~Song, M~~]]

[[Category: Liu Z]]

[[Category: Song M]]

[[Category: Xu Y]]

[[Category: Xue X]]

[[Category: Zhang Y]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5coi is ON HOLD  until Paper Publication
+==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==
+<StructureSection load='5coi' size='340' side='right'caption='[[5coi]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5coi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5COI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5COI FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=55K:1-({[(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)SULFONYL]AMINO}METHYL)CYCLOPENTANECARBOXYLIC+ACID'>55K</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5coi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5coi OCA], [https://pdbe.org/5coi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5coi RCSB], [https://www.ebi.ac.uk/pdbsum/5coi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5coi ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-Authors: Zhang, Y., Song, M., Liu, Z., Xue, X., Xu, Y.
+==See Also==
+*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
-Description: Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Xu, Y]]
+__TOC__
-[[Category: Zhang, Y]]
+</StructureSection>
-[[Category: Xue, X]]
+[[Category: Homo sapiens]]
-[[Category: Liu, Z]]
+[[Category: Large Structures]]
-[[Category: Song, M]]
+[[Category: Liu Z]]
+[[Category: Song M]]
+[[Category: Xu Y]]
+[[Category: Xue X]]
+[[Category: Zhang Y]]