5fai: Difference between revisions
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==EMG1 N1-Specific Pseudouridine Methyltransferase== | |||
<StructureSection load='5fai' size='340' side='right'caption='[[5fai]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FAI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fai OCA], [https://pdbe.org/5fai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fai RCSB], [https://www.ebi.ac.uk/pdbsum/5fai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fai ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN] Bowen-Conradi syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN] S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity).[UniProtKB:Q06287]<ref>PMID:20047967</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: BROWN PJ]] | |||
[[Category: Bountra C]] | |||
[[Category: DONG A]] | |||
[[Category: Edwards AM]] | |||
[[Category: LI Y]] | |||
[[Category: TEMPEL W]] | |||
[[Category: WU H]] | |||
[[Category: ZENG H]] | |||
Latest revision as of 06:44, 19 July 2023
EMG1 N1-Specific Pseudouridine Methyltransferase
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