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'''Unreleased structure'''


The entry 5fbx is ON HOLD
==Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor==
<StructureSection load='5fbx' size='340' side='right'caption='[[5fbx]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5fbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FBX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5W4:(3~{S})-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-3-PHENYL-3~{H}-ISOINDOL-1-ONE'>5W4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbx OCA], [https://pdbe.org/5fbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fbx RCSB], [https://www.ebi.ac.uk/pdbsum/5fbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbx ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


Authors: Tallant, C., Clark, P.G.K., Siejka, P., Fedorov, O., Nowak, R., Srikannathasan, V., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Dixon, D., Knapp, S.
==See Also==
 
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
Description: Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Nowak, R]]
__TOC__
[[Category: Fedorov, O]]
</StructureSection>
[[Category: Muller, S]]
[[Category: Homo sapiens]]
[[Category: Siejka, P]]
[[Category: Large Structures]]
[[Category: Knapp, S]]
[[Category: Arrowsmith CH]]
[[Category: Clark, P.G.K]]
[[Category: Bountra C]]
[[Category: Bountra, C]]
[[Category: Brennan PE]]
[[Category: Arrowsmith, C.H]]
[[Category: Clark PGK]]
[[Category: Dixon, D]]
[[Category: Dixon D]]
[[Category: Von Delft, F]]
[[Category: Edwards AM]]
[[Category: Edwards, A.M]]
[[Category: Fedorov O]]
[[Category: Tallant, C]]
[[Category: Knapp S]]
[[Category: Srikannathasan, V]]
[[Category: Muller S]]
[[Category: Nowak R]]
[[Category: Siejka P]]
[[Category: Srikannathasan V]]
[[Category: Tallant C]]
[[Category: Von Delft F]]
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