2rvj: Difference between revisions
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== | |||
<StructureSection load='2rvj' size='340' side='right' caption='[[2rvj | ==NMR structure of Epithelial splicing regulatory protein 1== | ||
<StructureSection load='2rvj' size='340' side='right'caption='[[2rvj]]' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2rvj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RVJ OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[2rvj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RVJ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rvj OCA], [https://pdbe.org/2rvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rvj RCSB], [https://www.ebi.ac.uk/pdbsum/2rvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rvj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ESRP1_HUMAN ESRP1_HUMAN] mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Allemand | [[Category: Homo sapiens]] | ||
[[Category: Guichou | [[Category: Large Structures]] | ||
[[Category: Labesse | [[Category: Allemand F]] | ||
[[Category: Yang | [[Category: Guichou J]] | ||
[[Category: Labesse G]] | |||
[[Category: Yang Y]] | |||
Latest revision as of 20:54, 12 April 2023
NMR structure of Epithelial splicing regulatory protein 1
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