|
|
| (15 intermediate revisions by 2 users not shown) |
| Line 1: |
Line 1: |
| {{STRUCTURE_1esa| PDB=1esa | SIZE=400| SCENE= |right|CAPTION= Pig elastase acyl-intermediate complex with sulfate and Ca+2 ion [[1esa]] }}
| | <StructureSection load='1eai' size='350' side='right' caption='Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow) (PDB code [[1eai]]).' scene='41/411401/Cv/3'> |
|
| |
|
| [[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see [[Serine Proteases]]. | | [[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. '''Panceatic ELA''' cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see <br /> |
| | *[[Protease]]<br /> |
| | *[[Serine Proteases]]. |
|
| |
|
| == Relevance == | | == Relevance == |
|
| |
|
| '''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation. | | '''ELA1''' in the pancreas correlates well with exocrine pancreatic functioning and is used as a function test for patients with pancreatitis. '''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation. |
|
| |
|
| == Disease == | | == Disease == |
| Line 11: |
Line 13: |
| Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid. | | Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid. |
|
| |
|
| ==3D structures of elastase== | | == Structural highlights == |
|
| |
|
| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | <scene name='41/411401/Cv/8'>Pig elastase</scene> (cyan, green) complex with <scene name='41/411401/Cv/9'>chymotrypsin/elastase isoinhibitor</scene> (magenta, yellow) (PDB code [[1eai]]). ELA <scene name='41/411401/Cv/10'>catalytic triad is Ser-His-Asp</scene>.<ref>PMID:7922044</ref> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
| |
|
| |
|
| * MMP12 See [[Matrix metalloproteinase]]
| | ==3D structures of elastase== |
| | | [[Elastase 3D structures]] |
| * MMP16 See [[Matrix metalloproteinase]]
| |
| | |
| * ELA1
| |
| | |
| **[[3mty]], [[3mu0]], [[3mu1]], [[3mu4]], [[3mu5]], [[3mu8]], [[3mnb]], [[3mnc]], [[3mns]], [[3mnx]], [[3mo3]], [[3mo6]], [[3mo9]], [[3moc]], [[3e3t]], [[2v0b]], [[2g4t]], [[2g4u]], [[2de8]], [[2blo]], [[2blq]], [[2a7c]], [[2a7j]], [[1gvk]], [[1qnj]], [[1lvy]], [[3est]], [[1est]], [[2oqu]], [[3odd]], [[3odf]], [[2bdc]] – pELA1 – pig<br />
| |
| **[[3hgn]] – pELA1+peptidyl inhibitor – neutron<br />
| |
| **[[3hgp]], [[2cv3]], [[2bdb]], [[2bcd]], [[2h1u]], [[1mmj]], [[1h9l]], [[1nes]], [[4est]], [[5est]], [[8est]], [[7est]], [[6est]] - pELA1+peptidyl inhibitor<br />
| |
| **[[1fzz]] – pELA1+ONO-6818<br />
| |
| **[[1qr3]], [[1qgf]], [[1bru]], [[1hv7]], [[1btu]] – pELA1+cyclic inhibitor<br />
| |
| **[[1okx]] – pELA1 + scyptolin<br />
| |
| **[[1e34]], [[1e35]], [[1e36]], [[1e37]], [[1e38]] – pELA1-gamma-lactam<br />
| |
| **[[1eai]] – pELA1+Ascaris inhibitor<br />
| |
| **[[2d26]] – pELA1+α-1-antitrypsin<br />
| |
| **[[1fle]] – pELA1+elafin<br />
| |
| **[[1b0e]], [[1b0f]] – pELA1+MDL<br />
| |
| **[[2v35]] – pELA1+JM54<br />
| |
| **[[2iot]] – pELA1+clavulanic acid<br />
| |
| **[[2de9]] – pELA1+tris<br />
| |
| **[[1uvo]], [[1uvp]], [[1lka]], [[1lkb]] – pELA1+ions<br />
| |
| **[[1gwa]] – pELA1+I3<br />
| |
| **[[1uo6]], [[1c1m]] – pELA1+Xe<br />
| |
| **[[1l0z]], [[1l1g]] - pELA1+Xe+Br<br />
| |
| **[[2bb4]], [[2bd2]], [[2bd3]], [[2bd4]], [[2bd5]], [[2bd7]], [[2bd8]], [[2bd9]], [[1hax]], [[1hay]], [[1haz]], [[1hb0]], [[1qix]] – pELA1+beta-casomorphin-7<br />
| |
| **[[2bda]] – pELA1+N-acetyl-NPI<br />
| |
| **[[1mcv]] – pELA1+squash inhibitor<br />
| |
| **[[1bma]] – pELA1+aminimide<br />
| |
| **[[1elf]], [[1elg]] – pELA1+peptidyl hydroxylamine<br />
| |
| **[[1eld]], [[1ele]], [[1elb]], [[1ela]], [[1elc]], [[2est]] – pELA1+anilide inhibitor<br />
| |
| **[[1esa]], [[1esb]] – pELA1 intermediate<br />
| |
| **[[1eas]], [[1eat]], [[1eau]] – pELA1+pyridine inhibitor<br />
| |
| **[[1inc]] – pELA1+benzoxazinone<br />
| |
| **[[1jim]], [[9est]], [[8est]] – pELA1+coumarin derivative<br />
| |
| **[[2fo9]], [[2foa]], [[2fob]], [[2foc]], [[2fod]], [[2foe]], [[2fof]], [[2fog]], [[2foh]] – pELA1+solvent<br />
| |
| **[[4k89]] – PaELA – ''Pseudomonas aeruginosa''<br />
| |
| **[[3dbk]] – PaELA+phophoramidon <br />
| |
| **[[1u4g]] – PaELA+HPI<br />
| |
| **[[1ezm]] - PaELA<br />
| |
| **[[1elt]] – ELA - salmon<br />
| |
| | |
| * ELA2
| |
|
| |
|
| **[[3q76]] – hELA2<br />
| | </StructureSection> |
| **[[3q77]] – hELA2+dihydropyrimidone inhibitor<br />
| |
| **[[2z7f]] – hELA2 peptidase domain +antileukoproteinase<br />
| |
| **[[2rg3]] – hELA2+sulfonic inhibitor<br />
| |
| **[[1h1b]], [[1ppg]], [[1hne]] – hELA2+inhibitor<br />
| |
| **[[1ppf]] – hELA2+ovomucoid<br />
| |
| **[[1b0f]] – hELA2+MDL101146<br />
| |
| **[[4nzl]] – hELA2 + protein <br />
| |
| **[[4wvp]] – hELA2 + activity-based probe <br />
| |
|
| |
|
| }}
| |
| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
