Elastase: Difference between revisions

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<StructureSection load='1eai' size='350' side='right' caption='Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow)  (PDB code [[1eai]]).' scene='41/411401/Cv/3'>


<StructureSection load='3hgp' size='350' side='right' caption='Structure of 6-aminohexanoate-dimer hydrolase complex with 6-aminohexanoate (PDB code [[2zm9]]).' scene=''>
[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins.  The ELAs are numbered according to their genes.  '''Panceatic ELA''' cleaves proteins at the carboxyl-terminal side of small neutral amino acids.  It cleaves Ala-Ala and Ala-Gly bonds.  <ref>PMID:12059069</ref>  For additional details see <br />
 
*[[Protease]]<br />
[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins.  The ELAs are numbered according to their genes.  Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids.  It cleaves Ala-Ala and Ala-Gly bonds.  <ref>PMID:12059069</ref>  For additional details see [[Serine Proteases]].
*[[Serine Proteases]].


== Relevance ==
== Relevance ==


'''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.
'''ELA1''' in the pancreas correlates well with exocrine pancreatic functioning and is used as a function test for patients with pancreatitis.  '''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.


== Disease ==
== Disease ==


Pulmonary emphysema is caused by the destruction of elastic fibre by elastase.  Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis.  Neutrophil elastase is involved in the blistering in bullose pemphigoid.
Pulmonary emphysema is caused by the destruction of elastic fibre by elastase.  Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis.  Neutrophil elastase is involved in the blistering in bullose pemphigoid.
</StructureSection>
==3D structures of elastase==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
== Structural highlights ==
{{#tree:id=OrganizedByTopic|openlevels=0|


* MMP12 See [[Matrix metalloproteinase]]
<scene name='41/411401/Cv/8'>Pig elastase</scene> (cyan, green) complex with <scene name='41/411401/Cv/9'>chymotrypsin/elastase isoinhibitor</scene> (magenta, yellow)  (PDB code [[1eai]]). ELA <scene name='41/411401/Cv/10'>catalytic triad is Ser-His-Asp</scene>.<ref>PMID:7922044</ref>


* MMP16 See [[Matrix metalloproteinase]]
==3D structures of elastase==
[[Elastase 3D structures]]


* ELA1
</StructureSection>
 
**[[3mty]], [[3mu0]], [[3mu1]], [[3mu4]], [[3mu5]], [[3mu8]], [[3mnb]], [[3mnc]], [[3mns]], [[3mnx]], [[3mo3]], [[3mo6]], [[3mo9]], [[3moc]], [[3e3t]], [[2v0b]], [[2g4t]], [[2g4u]], [[2de8]], [[2blo]], [[2blq]], [[2a7c]], [[2a7j]], [[1gvk]], [[1qnj]], [[1lvy]], [[3est]], [[1est]], [[2oqu]], [[3odd]], [[3odf]], [[2bdc]] – pELA1 – pig<br />
**[[3hgn]] – pELA1+peptidyl inhibitor – neutron<br />
**[[3hgp]], [[2cv3]], [[2bdb]], [[2bcd]], [[2h1u]], [[1mmj]], [[1h9l]], [[1nes]], [[4est]], [[5est]], [[8est]], [[7est]], [[6est]] - pELA1+peptidyl inhibitor<br />
**[[1fzz]] – pELA1+ONO-6818<br />
**[[1qr3]], [[1qgf]], [[1bru]], [[1hv7]], [[1btu]] – pELA1+cyclic inhibitor<br />
**[[1okx]] – pELA1 + scyptolin<br />
**[[1e34]], [[1e35]], [[1e36]], [[1e37]], [[1e38]] – pELA1-gamma-lactam<br />
**[[1eai]] – pELA1+Ascaris inhibitor<br />
**[[2d26]] – pELA1+α-1-antitrypsin<br />
**[[1fle]] – pELA1+elafin<br />
**[[1b0e]], [[1b0f]] – pELA1+MDL<br />
**[[2v35]] – pELA1+JM54<br />
**[[2iot]] – pELA1+clavulanic acid<br />
**[[2de9]] – pELA1+tris<br />
**[[1uvo]], [[1uvp]], [[1lka]], [[1lkb]] – pELA1+ions<br />
**[[1gwa]] – pELA1+I3<br />
**[[1uo6]], [[1c1m]] – pELA1+Xe<br />
**[[1l0z]], [[1l1g]] - pELA1+Xe+Br<br />
**[[2bb4]], [[2bd2]], [[2bd3]], [[2bd4]], [[2bd5]], [[2bd7]], [[2bd8]], [[2bd9]], [[1hax]], [[1hay]], [[1haz]], [[1hb0]], [[1qix]] – pELA1+beta-casomorphin-7<br />
**[[2bda]] – pELA1+N-acetyl-NPI<br />
**[[1mcv]] – pELA1+squash inhibitor<br />
**[[1bma]] – pELA1+aminimide<br />
**[[1elf]], [[1elg]] – pELA1+peptidyl hydroxylamine<br />
**[[1eld]], [[1ele]], [[1elb]], [[1ela]], [[1elc]], [[2est]] – pELA1+anilide inhibitor<br />
**[[1esa]], [[1esb]] – pELA1 intermediate<br />
**[[1eas]], [[1eat]], [[1eau]] – pELA1+pyridine inhibitor<br />
**[[1inc]] – pELA1+benzoxazinone<br />
**[[1jim]], [[9est]], [[8est]] – pELA1+coumarin derivative<br />
**[[2fo9]], [[2foa]], [[2fob]], [[2foc]], [[2fod]], [[2foe]], [[2fof]], [[2fog]], [[2foh]] – pELA1+solvent<br />
**[[4k89]] – PaELA – ''Pseudomonas aeruginosa''<br />
**[[3dbk]] – PaELA+phophoramidon <br />
**[[1u4g]] – PaELA+HPI<br />
**[[1ezm]] - PaELA<br />
**[[1elt]] – ELA - salmon<br />
 
* ELA2
 
**[[3q76]] – hELA2<br />
**[[3q77]] – hELA2+dihydropyrimidone inhibitor<br />
**[[2z7f]] – hELA2 peptidase domain +antileukoproteinase<br />
**[[2rg3]] – hELA2+sulfonic inhibitor<br />
**[[1h1b]], [[1ppg]], [[1hne]] – hELA2+inhibitor<br />
**[[1ppf]] – hELA2+ovomucoid<br />
**[[1b0f]] – hELA2+MDL101146<br />
**[[4nzl]] – hELA2 + protein <br />
**[[4wvp]] – hELA2 + activity-based probe <br />


}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 10:17, 18 June 2019

Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow) (PDB code 1eai).

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References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Guido Hansen, Jaime Prilusky, Michal Harel

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