5he2: Difference between revisions

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'''Unreleased structure'''


The entry 5he2 is ON HOLD
==Bovine GRK2 in complex with Gbetagamma subunits and CCG224406==
<StructureSection load='5he2' size='340' side='right'caption='[[5he2]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5he2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HE2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F0S:(4~{S})-4-[3-[(2,6-DIMETHOXYPHENYL)METHYLCARBAMOYL]-4-FLUORANYL-PHENYL]-~{N}-(1~{H}-INDAZOL-5-YL)-6-METHYL-2-OXIDANYLIDENE-3,4-DIHYDRO-1~{H}-PYRIMIDINE-5-CARBOXAMIDE'>F0S</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5he2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5he2 OCA], [https://pdbe.org/5he2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5he2 RCSB], [https://www.ebi.ac.uk/pdbsum/5he2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5he2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARBK1_BOVIN ARBK1_BOVIN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity).


Authors: Cato, M.C., Tesmer, J.J.G.
==See Also==
 
*[[Beta adrenergic receptor kinase 3D structures|Beta adrenergic receptor kinase 3D structures]]
Description: Bovine GRK2 in complex with Gbetagamma subunits and CCG224406
*[[Transducin 3D structures|Transducin 3D structures]]
[[Category: Unreleased Structures]]
__TOC__
[[Category: Cato, M.C]]
</StructureSection>
[[Category: Tesmer, J.J.G]]
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cato MC]]
[[Category: Tesmer JJG]]
[[Category: Waninger-Saroni J]]
Retrieved from "https://proteopedia.org/5he2"