5hen: Difference between revisions
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New page: '''Unreleased structure''' The entry 5hen is ON HOLD Authors: Tallant, C., Lori, C., Pasquo, A., Chiaraluce, R., Consalvi, V., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A.... |
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==Crystal structure of the N-terminus R100L bromodomain mutant of human BRD2== | |||
<StructureSection load='5hen' size='340' side='right'caption='[[5hen]], [[Resolution|resolution]] 1.79Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hen]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HEN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hen OCA], [https://pdbe.org/5hen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hen RCSB], [https://www.ebi.ac.uk/pdbsum/5hen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hen ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> | |||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Chiaraluce R]] | ||
[[Category: | [[Category: Consalvi V]] | ||
[[Category: | [[Category: Edwards AM]] | ||
[[Category: | [[Category: Knapp S]] | ||
[[Category: | [[Category: Lori C]] | ||
[[Category: Newman JA]] | |||
[[Category: Pasquo A]] | |||
[[Category: Tallant C]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 07:33, 9 August 2023
Crystal structure of the N-terminus R100L bromodomain mutant of human BRD2
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