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==Crystal structure of the K499G mutant of NanB sialidase from Streptococcus pneumoniae==
==Crystal structure of the K499G mutant of NanB sialidase from Streptococcus pneumoniae==
<StructureSection load='4xmi' size='340' side='right' caption='[[4xmi]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
<StructureSection load='4xmi' size='340' side='right'caption='[[4xmi]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4xmi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XMI FirstGlance]. <br>
<table><tr><td colspan='2'>[[4xmi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XMI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xmi OCA], [http://pdbe.org/4xmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xmi RCSB], [http://www.ebi.ac.uk/pdbsum/4xmi PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xmi OCA], [https://pdbe.org/4xmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xmi RCSB], [https://www.ebi.ac.uk/pdbsum/4xmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xmi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NANB_STRPN NANB_STRPN]
==See Also==
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Exo-alpha-sialidase]]
[[Category: Large Structures]]
[[Category: Brear, P]]
[[Category: Streptococcus pneumoniae TIGR4]]
[[Category: Allosteric inhibitor]]
[[Category: Brear P]]
[[Category: Crystallization artefact]]
[[Category: Drug design]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]
[[Category: Intramolecular trans-sialidase]]
[[Category: Neuraminidase]]
[[Category: Serendipitous allosteric site]]

Latest revision as of 10:49, 10 January 2024

Crystal structure of the K499G mutant of NanB sialidase from Streptococcus pneumoniae

4xmi, resolution 1.97Å

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