5b1w: Difference between revisions

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'''Unreleased structure'''


The entry 5b1w is ON HOLD  until Paper Publication
==Crystal structure of human dendritic cell inhibitory receptor (DCIR) C-type lectin domain in ligand-free form==
<StructureSection load='5b1w' size='340' side='right'caption='[[5b1w]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5b1w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B1W FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b1w OCA], [https://pdbe.org/5b1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b1w RCSB], [https://www.ebi.ac.uk/pdbsum/5b1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b1w ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CLC4A_HUMAN CLC4A_HUMAN] May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.<ref>PMID:10438934</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human dendritic cell inhibitory receptor (DCIR) is a C-type lectin receptor expressed in classical dendritic cells and accepts several oligosaccharide ligands including N-glycans. Here, we report the crystal structures of human DCIR C-type lectin domains in the absence and presence of a branched N-glycan unit. The domain has a typical C-type lectin fold and two bound calcium ions. In the ligand-bound form, the disaccharide unit (GlcNAcbeta1-2Man) acceptably fits the electron density map, indicating that it forms the main epitope. The recognition of the nonterminal N-glycan unit explains the relatively broad specificity of this lectin.


Authors: Nagae, M., Yamaguchi, Y.
Crystal structure of human dendritic cell inhibitory receptor C-type lectin domain reveals the binding mode with N-glycan.,Nagae M, Ikeda A, Hanashima S, Kojima T, Matsumoto N, Yamamoto K, Yamaguchi Y FEBS Lett. 2016 Apr;590(8):1280-8. doi: 10.1002/1873-3468.12162. Epub 2016 Apr 6. PMID:27015765<ref>PMID:27015765</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Nagae, M]]
<div class="pdbe-citations 5b1w" style="background-color:#fffaf0;"></div>
[[Category: Yamaguchi, Y]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Nagae M]]
[[Category: Yamaguchi Y]]
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