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==Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W==
==Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W==
<StructureSection load='5aek' size='340' side='right' caption='[[5aek]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='5aek' size='340' side='right'caption='[[5aek]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5aek]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AEK FirstGlance]. <br>
<table><tr><td colspan='2'>[[5aek]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AEK FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uee|4uee]], [[4uef|4uef]], [[4uez|4uez]], [[4uf4|4uf4]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ulp1_peptidase Ulp1 peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.68 3.4.22.68] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aek OCA], [https://pdbe.org/5aek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aek RCSB], [https://www.ebi.ac.uk/pdbsum/5aek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aek ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aek OCA], [http://pdbe.org/5aek PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aek RCSB], [http://www.ebi.ac.uk/pdbsum/5aek PDBsum]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN]] Defects in SUMO1 are the cause of non-syndromic orofacial cleft type 10 (OFC10) [MIM:[http://omim.org/entry/613705 613705]]; also called non-syndromic cleft lip with or without cleft palate 10. OFC10 is a birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=A chromosomal aberation involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.<ref>PMID:16990542</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SENP2_HUMAN SENP2_HUMAN]] Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity).<ref>PMID:12192048</ref> <ref>PMID:11896061</ref> [[http://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.<ref>PMID:9019411</ref> <ref>PMID:9162015</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref> 
[https://www.uniprot.org/uniprot/SENP2_HUMAN SENP2_HUMAN] Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity).<ref>PMID:12192048</ref> <ref>PMID:11896061</ref>  
 
==See Also==
*[[SUMO 3D Structures|SUMO 3D Structures]]
*[[Sentrin-specific protease|Sentrin-specific protease]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ulp1 peptidase]]
[[Category: Homo sapiens]]
[[Category: Castillo, V]]
[[Category: Large Structures]]
[[Category: Espargaro, A]]
[[Category: Castillo V]]
[[Category: Gallego, P]]
[[Category: Espargaro A]]
[[Category: Grana-Montes, R]]
[[Category: Gallego P]]
[[Category: Lange, R]]
[[Category: Grana-Montes R]]
[[Category: Lindorff-Larsend, K]]
[[Category: Lange R]]
[[Category: Papaleo, E]]
[[Category: Lindorff-Larsend K]]
[[Category: Reverter, D]]
[[Category: Papaleo E]]
[[Category: Torrent, J]]
[[Category: Reverter D]]
[[Category: Ventura, S]]
[[Category: Torrent J]]
[[Category: Folding evolution]]
[[Category: Ventura S]]
[[Category: Hydrolase]]
[[Category: Senp]]
[[Category: Sumo]]
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