Fibritin: Difference between revisions
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<StructureSection load='1ox3' size='340' side='right' caption='Structure of fibritin N-terminal and foldon domains (PDB code [[1ox3]]).' scene=''> | <StructureSection load='1ox3' size='340' side='right' caption='Structure of fibritin N-terminal and foldon domains (PDB code [[1ox3]]).' scene='59/596418/Cv/1'> | ||
== Function == | == Function == | ||
'''Fibritin''' (Fib) is a | '''Fibritin''' (Fib) is a structural protein of virus. Fib promotes the assembly of the long tail fibers (whiskers) and their attachment to the virus tail baseplate. Fib is also responsible for the retraction of the tail fibers in adverse environment<ref>PMID:9261070</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
Fib structure is composed of N-terminal domain which is responsible for attachment to the phage, a central 500A domain made of triple-helix coiled coil and the C-terminal domain ('''foldon''') – residues 458-484 – which is the trimerization domain. | <scene name='59/596418/Cv/3'>Fib is trimer</scene>. Fib structure is composed of N-terminal domain which is responsible for attachment to the phage, a central 500A domain made of triple-helix coiled coil and the C-terminal domain ('''foldon''') – residues 458-484 – which is the trimerization domain. | ||
</StructureSection> | </StructureSection> | ||
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[[1aa0]] – T4Fib residues 371-483 – T4 bacteriophage<br /> | [[1aa0]] – T4Fib residues 371-483 – T4 bacteriophage<br /> | ||
[[1avy]] – T4Fib residues 413-486 (mutant)<br /> | [[1avy]] – T4Fib residues 413-486 (mutant)<br /> | ||
[[2ww6]], [[2ww7]], [[4ncu]], [[4ncv]], [[4ncw]] – T4Fib foldon <br /> | [[2ww6]], [[2ww7]], [[4ncu]], [[4ncv]], [[4ncw]] – T4Fib foldon 458-484<br /> | ||
[[1u0p]] – T4Fib foldon - NMR<br /> | [[1u0p]] – T4Fib foldon - NMR<br /> | ||
[[1rfo]], [[2kbl]] – T4Fib foldon (mutant) - NMR<br /> | [[1rfo]], [[2kbl]] – T4Fib foldon (mutant) - NMR<br /> | ||
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[[1v1h]], [[1v1i]] – Fib shaft domain/T4Fib foldon domain - Adenovirus<br /> | [[1v1h]], [[1v1i]] – Fib shaft domain/T4Fib foldon domain - Adenovirus<br /> | ||
[[3a1m]] – T4Fib foldon/GP5C <br /> | [[3a1m]] – T4Fib foldon/GP5C <br /> | ||
[[6z97]] – ScvFib – SARS coronavirus – Cryo EM<br /> | |||
[[6crv]], [[6crw]], [[6crx]], [[6crz]], [[6cs0]], [[6cs1]], [[6cs2]] – ScvFib (mutant) <br /> | |||
