Fibronectin: Difference between revisions

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[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin FnI<sub>4-5</sub> fragment [[1fbr]]]]
<StructureSection load='3m7p' size='350' side='right' scene='43/430871/Cv/2' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>
 
<StructureSection load='3m7p' size='350' side='right' scene='' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>


== Function ==
== Function ==
Line 13: Line 11:
== Disease ==
== Disease ==


Overexpression of Fn1 is associated with lung cancer.
Overexpression of Fn1 is associated with lung cancer<ref>PMID:16397245</ref>.


== Structural insights ==
== Structural insights ==


Fn is a dimer of homologous monomers linked by S-S bond.  Each monomer contains 3 types of modules: FnI, FnII and FnIII.  Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD).  
<scene name='43/430871/Cv/3'>Fn is a dimer of homologous monomers</scene> linked by S-S bond.  Each monomer contains 3 types of modules: FnI, FnII and FnIII.  Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD).  
</StructureSection>


== 3D Structures of Fibronectin ==
== 3D Structures of Fibronectin ==
[[Fibronectin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
* Fn module FnI
 
**[[3m7p]] – hFn GBD – human<br />
**[[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br />
**[[3gxe]], [[3ejh]] – hFn 8-9FnI+collagen alpha-1<br />
**[[1fbr]] - hFn 4-5FnI - NMR<br />
**[[2rky]], [[2rl0]] – hFn 4-5FnI+Fn binding peptide<br />
**[[2rkz]], [[3cal]], [[3zrz]] - hFn 2-3FnI+Fn binding peptide<br />
**[[2cg6]], [[2cg7]] - hFn 2-3FnI<br />
**[[2cku]] - hFn 2-3FnI – NMR<br />
**[[1o9a]] - hFn 1-2FnI+B3 from FNBB – NMR<br />
**[[2ec3]] – hFn 11FnI – NMR<br />
**[[3r8q]] – hFn 12-14FnI<br />
**[[1qgb]] – hFn FnI N-terminal - NMR<br />
**[[2ck2]] – hFn (mutant) core swapped<br />
**[[1j8k]] – hFn extra domain 2 – NMR<br />
**[[1fnh]] – hFn heparin and integrin binding domains<br />
**[[2qbw]], [[3ch8]] – hFn-PDZ fusion<br />
**[[4gh7]] – hFn residues 1173-1448 + Neutrophil gelatinase-associated lipocalin
 
* Fn module FnII
 
**[[2fn2]] – hFn 2FnII – NMR
 
* Fn module FnIII
 
**[[1q38]], [[1x3d]], [[1x4x]], [[1x5x]] - hFn FnIII – NMR<br />
**[[2h41]], [[2h45]] – hFn 2FnIII – NMR<br />
**[[1oww]] - hFn 1FnIII – NMR<br />
**[[2ha1]] - hFn 1-2FnIII – NMR<br />
**[[2crm]] - hFn 4FnIII – NMR<br />
**[[2crz]] - hFn 5FnIII – NMR<br />
**[[1fna]], [[1ttf]], [[1ttg]] – hFn 10FnIII<br />
**[[4mmx]] - hFn 10FnIII + integrin α V + integrin β 3<br />
**[[4mmy]], [[4mmz]] - hFn 10FnIII (mutant) + integrin α V + integrin β 3<br />
**[[2ocf]] - hFn 10FnIII+estrogen receptor ligand-binding domain<br />
**[[1fnf]] – hFn 7-10FnIII<br />
**[[2fnb]] – hFn FnIII ed-b domain – NMR<br />
**[[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR<br />
**[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens''
 
* Fn module FnI+FnII


**[[3mql]] – hFn 6FnI+2FnII+7FnI
}}
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 08:14, 1 July 2019

Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code 3m7p)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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