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==Crystal structure of Rv2466c and oxidoreductase from Mycobacterium tuberculosis in its reduced state==
==Crystal structure of Rv2466c and oxidoreductase from Mycobacterium tuberculosis in its reduced state==
<StructureSection load='4zil' size='340' side='right' caption='[[4zil]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
<StructureSection load='4zil' size='340' side='right'caption='[[4zil]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zil]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZIL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zil]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZIL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.507&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nxi|4nxi]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zil OCA], [http://pdbe.org/4zil PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zil RCSB], [http://www.ebi.ac.uk/pdbsum/4zil PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zil OCA], [https://pdbe.org/4zil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zil RCSB], [https://www.ebi.ac.uk/pdbsum/4zil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zil ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRLR_MYCTU TRLR_MYCTU] In vitro, the reduced form of Rv2466c catalyzes the reduction and activation of TP053, which is a thienopyrimidine derivative drug that can kill both replicating and non-replicating M.tuberculosis.<ref>PMID:24877756</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Albesa-Jove, D]]
[[Category: Large Structures]]
[[Category: Comino, N]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Guerin, M E]]
[[Category: Albesa-Jove D]]
[[Category: Tersa, M]]
[[Category: Comino N]]
[[Category: Urresti, S]]
[[Category: Guerin ME]]
[[Category: Oxidoreductase]]
[[Category: Tersa M]]
[[Category: Urresti S]]
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