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==The structure of the Bt1.8 peptide synthesized by solid-phase method==
==The structure of the Bt1.8 peptide synthesized by solid-phase method==
<StructureSection load='2nay' size='340' side='right' caption='[[2nay]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2nay' size='340' side='right'caption='[[2nay]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2nay]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NAY FirstGlance]. <br>
<table><tr><td colspan='2'>[[2nay]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_betulinus Conus betulinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NAY FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nay OCA], [http://pdbe.org/2nay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nay RCSB], [http://www.ebi.ac.uk/pdbsum/2nay PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nay OCA], [https://pdbe.org/2nay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nay RCSB], [https://www.ebi.ac.uk/pdbsum/2nay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nay ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CA18_CONBE CA18_CONBE] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin inhibits mammalian alpha-3-beta-2/CHRNA3-CHRNB2 nAChR (IC(50)=9.4 nM (rat), IC(50)=8.8 nM (human)), as well as the subunit chimera alpha-6/alpha-3-beta-2-beta-3 nAChR (CHRNA6/CHRNA3-CHRNB2-CHRNB3)(IC(50)=2.1 nM (rat), IC(50)=1.7 nM (human)). Binds to rat alpha-6/alpha-3-beta-2-beta-3 more rapidly than to alpha-3-beta-2, and dissociates more rapidly from alpha-3-beta-2 than from alpha-6/alpha-3-beta-2-beta-3.<ref>PMID:34008858</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Biling, H]]
[[Category: Conus betulinus]]
[[Category: Chenyun, G]]
[[Category: Large Structures]]
[[Category: De novo protein]]
[[Category: Biling H]]
[[Category: Helix]]
[[Category: Chenyun G]]

Latest revision as of 01:13, 21 November 2024

The structure of the Bt1.8 peptide synthesized by solid-phase method

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