5f70: Difference between revisions

Latest revision as of 06:40, 19 July 2023

Crystal structures of human TIM members

Structural highlights

5f70 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HAVR1_HUMAN May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.^[1] (Microbial infection) Acts as a receptor for hepatitis A virus (PubMed:9658108). Acts as a receptor for ebolavirus and marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921).^[2] ^[3] ^[4]

References

↑ van Timmeren MM, van den Heuvel MC, Bailly V, Bakker SJ, van Goor H, Stegeman CA. Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J Pathol. 2007 Jun;212(2):209-17. PMID:17471468 doi:https://dx.doi.org/10.1002/path.2175
↑ Kondratowicz AS, Lennemann NJ, Sinn PL, Davey RA, Hunt CL, Moller-Tank S, Meyerholz DK, Rennert P, Mullins RF, Brindley M, Sandersfeld LM, Quinn K, Weller M, McCray PB Jr, Chiorini J, Maury W. T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8426-31. doi:, 10.1073/pnas.1019030108. Epub 2011 May 2. PMID:21536871 doi:https://dx.doi.org/10.1073/pnas.1019030108
↑ Meertens L, Carnec X, Lecoin MP, Ramdasi R, Guivel-Benhassine F, Lew E, Lemke G, Schwartz O, Amara A. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell Host Microbe. 2012 Oct 18;12(4):544-57. doi: 10.1016/j.chom.2012.08.009. PMID:23084921 doi:https://dx.doi.org/10.1016/j.chom.2012.08.009
↑ Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan GG. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J Virol. 1998 Aug;72(8):6621-8. PMID:9658108

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OCA

[1] van Timmeren MM, van den Heuvel MC, Bailly V, Bakker SJ, van Goor H, Stegeman CA. Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J Pathol. 2007 Jun;212(2):209-17. PMID:17471468 doi:https://dx.doi.org/10.1002/path.2175

[2] Kondratowicz AS, Lennemann NJ, Sinn PL, Davey RA, Hunt CL, Moller-Tank S, Meyerholz DK, Rennert P, Mullins RF, Brindley M, Sandersfeld LM, Quinn K, Weller M, McCray PB Jr, Chiorini J, Maury W. T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8426-31. doi:, 10.1073/pnas.1019030108. Epub 2011 May 2. PMID:21536871 doi:https://dx.doi.org/10.1073/pnas.1019030108

[3] Meertens L, Carnec X, Lecoin MP, Ramdasi R, Guivel-Benhassine F, Lew E, Lemke G, Schwartz O, Amara A. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell Host Microbe. 2012 Oct 18;12(4):544-57. doi: 10.1016/j.chom.2012.08.009. PMID:23084921 doi:https://dx.doi.org/10.1016/j.chom.2012.08.009

[4] Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan GG. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J Virol. 1998 Aug;72(8):6621-8. PMID:9658108

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
 ==Crystal structures of human TIM members==
-<StructureSection load='5f70' size='340' side='right' caption='[[5f70]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='5f70' size='340' side='right'caption='[[5f70]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5f70]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F70 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F70 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5f70]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F70 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f71|5f71]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f70 OCA], [http://pdbe.org/5f70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f70 RCSB], [http://www.ebi.ac.uk/pdbsum/5f70 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f70 OCA], [https://pdbe.org/5f70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f70 RCSB], [https://www.ebi.ac.uk/pdbsum/5f70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f70 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/HAVR1_HUMAN HAVR1_HUMAN]] May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.<ref>PMID:17471468</ref>   (Microbial infection) Acts as a receptor for hepatitis A virus (PubMed:9658108). Acts as a receptor for ebolavirus and marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921).<ref>PMID:21536871</ref> <ref>PMID:23084921</ref> <ref>PMID:9658108</ref>
+[https://www.uniprot.org/uniprot/HAVR1_HUMAN HAVR1_HUMAN] May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.<ref>PMID:17471468</ref>   (Microbial infection) Acts as a receptor for hepatitis A virus (PubMed:9658108). Acts as a receptor for ebolavirus and marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921).<ref>PMID:21536871</ref> <ref>PMID:23084921</ref> <ref>PMID:9658108</ref>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Gao, G F]]
+[[Category: Homo sapiens]]
-[[Category: Lu, G]]
+[[Category: Large Structures]]
-[[Category: Qi, J]]
+[[Category: Gao GF]]
-[[Category: Wang, H]]
+[[Category: Lu G]]
-[[Category: Ebola virus]]
+[[Category: Qi J]]
-[[Category: Htim]]
+[[Category: Wang H]]
-[[Category: Immune system]]
-[[Category: Receptor]]

5f70: Difference between revisions

Latest revision as of 06:40, 19 July 2023

Crystal structures of human TIM members

Structural highlights

Function

References

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