2fh7: Difference between revisions

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==Crystal structure of the phosphatase domains of human PTP SIGMA==
==Crystal structure of the phosphatase domains of human PTP SIGMA==
<StructureSection load='2fh7' size='340' side='right' caption='[[2fh7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2fh7' size='340' side='right'caption='[[2fh7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2fh7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FH7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2fh7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FH7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPRS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fh7 OCA], [https://pdbe.org/2fh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fh7 RCSB], [https://www.ebi.ac.uk/pdbsum/2fh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fh7 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2fh7 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fh7 OCA], [http://pdbe.org/2fh7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fh7 RCSB], [http://www.ebi.ac.uk/pdbsum/2fh7 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2fh7 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN]] Interacts with LAR-interacting protein LIP.1.  
[https://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN] Interacts with LAR-interacting protein LIP.1.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/2fh7_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/2fh7_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Almo, S C]]
[[Category: Almo SC]]
[[Category: Alvarado, J]]
[[Category: Alvarado J]]
[[Category: Atwell, S]]
[[Category: Atwell S]]
[[Category: Bain, K T]]
[[Category: Bain KT]]
[[Category: Burley, S K]]
[[Category: Burley SK]]
[[Category: Freeman, J C]]
[[Category: Freeman JC]]
[[Category: Kearins, M C]]
[[Category: Kearins MC]]
[[Category: Koss, J]]
[[Category: Koss J]]
[[Category: Maletic, M]]
[[Category: Maletic M]]
[[Category: Structural genomic]]
[[Category: Ozyurt S]]
[[Category: Ozyurt, S]]
[[Category: Powell A]]
[[Category: Powell, A]]
[[Category: Rooney I]]
[[Category: Rooney, I]]
[[Category: Russell M]]
[[Category: Russell, M]]
[[Category: Sauder JM]]
[[Category: Sauder, J M]]
[[Category: Smith D]]
[[Category: Smith, D]]
[[Category: Thompson DA]]
[[Category: Thompson, D A]]
[[Category: Udupi R]]
[[Category: Udupi, R]]
[[Category: Wasserman SR]]
[[Category: Wasserman, S R]]
[[Category: Dual domain phosphatase]]
[[Category: Hydrolase]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
[[Category: PSI, Protein structure initiative]]
[[Category: Receptor protein tyrosine phosphatase]]
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