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==Crystal structure of spermidine synthase from Pyrococcus horikoshii OT3, P1 form==
==Crystal structure of spermidine synthase from Pyrococcus horikoshii OT3, P1 form==
<StructureSection load='2zsu' size='340' side='right' caption='[[2zsu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2zsu' size='340' side='right'caption='[[2zsu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2zsu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZSU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2zsu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZSU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG3:1-{4-[(3-AMINOPROPYL)AMINO]BUTYL}GUANIDINE'>AG3</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG3:1-{4-[(3-AMINOPROPYL)AMINO]BUTYL}GUANIDINE'>AG3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsu OCA], [http://pdbe.org/2zsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zsu RCSB], [http://www.ebi.ac.uk/pdbsum/2zsu PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsu OCA], [https://pdbe.org/2zsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zsu RCSB], [https://www.ebi.ac.uk/pdbsum/2zsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zsu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPEE_PYRHO SPEE_PYRHO]] Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine (By similarity).[HAMAP-Rule:MF_00198]  
[https://www.uniprot.org/uniprot/SPEE_PYRHO SPEE_PYRHO] Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine (By similarity).[HAMAP-Rule:MF_00198]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/2zsu_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/2zsu_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Spermidine Synthase|Spermidine Synthase]]
*[[Spermidine synthase 3D structures|Spermidine synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pyrococcus shinkaii]]
[[Category: Large Structures]]
[[Category: Spermidine synthase]]
[[Category: Pyrococcus horikoshii]]
[[Category: Kunishima, N]]
[[Category: Kunishima N]]
[[Category: Mizutani, H]]
[[Category: Mizutani H]]
[[Category: Aminopropylagmatine]]
[[Category: Polyamine biosynthesis]]
[[Category: Spermidine biosynthesis]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2zsu"