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==Crystal structure of TetR triple mutant (H64K, S135L, S138I)==
==Crystal structure of TetR triple mutant (H64K, S135L, S138I)==
<StructureSection load='3fk6' size='340' side='right' caption='[[3fk6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3fk6' size='340' side='right'caption='[[3fk6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3fk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FK6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3fk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FK6 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vke|2vke]], [[2o7o|2o7o]], [[2vkv|2vkv]], [[2tct|2tct]], [[3fk7|3fk7]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tetR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fk6 OCA], [https://pdbe.org/3fk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fk6 RCSB], [https://www.ebi.ac.uk/pdbsum/3fk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fk6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fk6 OCA], [http://pdbe.org/3fk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fk6 RCSB], [http://www.ebi.ac.uk/pdbsum/3fk6 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TETR2_ECOLX TETR2_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.  
[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/3fk6_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/3fk6_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Tetracycline repressor protein|Tetracycline repressor protein]]
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Gmeiner, P]]
[[Category: Large Structures]]
[[Category: Hillen, W]]
[[Category: Gmeiner P]]
[[Category: Klieber, M A]]
[[Category: Hillen W]]
[[Category: Lochner, S]]
[[Category: Klieber MA]]
[[Category: Muller, Y A]]
[[Category: Lochner S]]
[[Category: Scholz, O]]
[[Category: Muller YA]]
[[Category: 4-de-dimethylamino-anhydrotetracycline]]
[[Category: Scholz O]]
[[Category: Altered inducer specificity]]
[[Category: Antibiotic resistance]]
[[Category: Bacterial transcription regulation]]
[[Category: Dna-binding]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Repressor]]
[[Category: Tetracycline repressor]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
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